Lihe Liu

Lihe Liu

Postdoctoral Researcher

MD Anderson Cancer Center

The University of Texas

Research Interests

Computational Pathology
Single Cell & Spatial Biology
Multi-omics Integration

About

I am currently a postdoctoral researcher in the Department of Translational Molecular Pathology at MD Anderson Cancer Center, advised by Dr. Lulu Shang and Dr. Yinyin Yuan. Previously, I obtained my Ph.D. in Animal Sciences (Computational Biology track) and M.S. in Computer Sciences from UW-Madison, advised by with Dr. Francisco Peñagaricano.

During my graduate studies, I used bioinformatics and computational approaches to characterize the impact of maternal dietary methionine on the offspring transcriptome and epigenome in cows, yielding insights into fetal programming in bovine genome. My current research focuses on developing scalable and interpretable learning models for computational pathology and spatial/single-cell genomics, aiming to elucidate human disease mechanisms across diverse biological systems and drive improvements in patient care.

News

2025-03

Joined MD Anderson Cancer Center as PostDoc researcher.

2024-01

Joined Sanford Burnham Prebys Medical Discovery Institute as PostDoc researcher.

Selected Publications

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EnrichKit: a multi-omics tool for livestock research

EnrichKit: a multi-omics tool for livestock research

Lihe Liu, Francisco Peñagaricano

Frontiers in Genetics 2025

ecPath detects ecDNA in tumors from histopathology images

ecPath detects ecDNA in tumors from histopathology images

Mudra Choudhury*, Lihe Liu*, Anamika Yadav, Owen Chapman, Zahra Ahmadi, Raneen Younis, and

bioRxiv 2024 (Under review)

Maternal diet induces persistent DNA methylation changes in the muscle of beef calves

Maternal diet induces persistent DNA methylation changes in the muscle of beef calves

Rocío Amorín*, Lihe Liu*, Philipe Moriel, Nicolás DiLorenzo, Phillip Lancaster, Francisco Peñagaricano

Scientific Reports 2023

Maternal methionine supplementation during gestation alters alternative splicing and DNA methylation in bovine skeletal muscle

Maternal methionine supplementation during gestation alters alternative splicing and DNA methylation in bovine skeletal muscle

Lihe Liu, Rocío Amorín, Philipe Moriel, Nicolás DiLorenzo, Phillip A Lancaster, Francisco Peñagaricano

BMC genomics 2021

Differential network analysis of bovine muscle reveals changes in gene coexpression patterns in response to changes in maternal nutrition

Differential network analysis of bovine muscle reveals changes in gene coexpression patterns in response to changes in maternal nutrition

Lihe Liu, Rocío Amorín, Philipe Moriel, Nicolás DiLorenzo, Phillip A Lancaster, Francisco Peñagaricano

BMC genomics 2020