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publications

Gestational and lactational exposure to gossypol alters the testis transcriptome

Published in BMC Genomics, 2020

Our findings provide evidence that maternal exposure to gossypol alters male reproductive function in the offspring, with potential lasting or lifelong negative consequences. Read more

Genetic dissection of reproductive performance of dairy cows under heat stress

Published in Animal Genetics, 2020

Overall, our findings contribute to a better understanding of the genetics underlying the reproductive performance of dairy cattle under heat stress conditions and point out novel genomic strategies for improving thermotolerance and fertility via marker-assisted breeding Read more

Differential network analysis of bovine muscle reveals changes in gene coexpression patterns in response to changes in maternal nutrition

Published in BMC Genomics, 2020

Overall, our findings provide evidence that maternal nutrition can significantly alter gene coexpression patterns in the offspring, and some of these perturbations are mediated by changes in DNA methylation. Read more

Histological and transcriptomic analysis of adipose and muscle of dairy calves supplemented with 5-hydroxytryptophan

Published in Scientific Reports, 2021

Our data highlights tissue specific genes and pathways impacted by increased peripheral serotonin. In the adipose, serotonin impacted the expression of genes involved in pathways related to intracellular signal transduction mechanisms, lipid metabolism and fatty acid biosynthesis, cell proliferation and differentiation Read more

Effect of natural pre-luteolytic prostaglandin F2α pulses on the bovine luteal transcriptome during spontaneous luteal regression

Published in Biology of Reproduction, 2021

Thus, early, subluteolytic PGF pulses impact the luteal transcriptome, though not by altering steroidogenesis or causing direct inhibition of cellular function. Rather, small pulses alter pathways resulting in the removal of cellular support systems, which may sensitize the CL to later pulses of PGF. Read more

Maternal methionine supplementation during gestation alters alternative splicing and DNA methylation in bovine skeletal muscle

Published in BMC Genomics, 2021

Overall, our findings provide evidence that a prenatal diet rich in methyl donors can significantly alter the offspring transcriptome, including changes in isoform expression and exon usage, and some of these changes are mediated by changes in DNA methylation. Read more

Impact of Fluoxetine Treatment and Folic Acid Supplementation on the Mammary Gland Transcriptome During Peak Lactation

Published in Frontiers in Pharmacology, 2022

In conclusion, peripartal SSRI use and folic acid supplementation altered critical genes related to milk synthesis and mammary gland function that are important to a successful lactation. However, folic acid supplementation did not reverse changes in the mammary gland transcriptome altered by peripartal SSRI treatment. Read more

Maternal diet induces persistent DNA methylation changes in the muscle of beef calves

Published in Scientific Reports, 2023

Overall, our study provides evidence that a maternal methionine-rich diet altered fetal epigenome, and some of these epigenetic changes persisted over time. Read more

The metabolomic composition of the oviductal fluid is controlled by the periovulatory hormonal context in Bos indicus cows

Published in Biology of Reproduction, 2024

We concluded that the periovulatory endocrine milieu regulates the composition of the oviductal fluid. Read more

software

EnrichKit

The goal of EnrichKit is to provide user-friendly functions to facilitate genomics research in livestock species. Currently, five functions ware implemented, ID Conversion, Genomic Coordinates Matching, P-value Aggregration, Over-representation Analysis and Gene Set Enrichment Analysis

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