Published in Biology of Reproduction, 2024
We concluded that the periovulatory endocrine milieu regulates the composition of the oviductal fluid. Read more
Published in Scientific Reports, 2023
Overall, our study provides evidence that a maternal methionine-rich diet altered fetal epigenome, and some of these epigenetic changes persisted over time. Read more
Published in Frontiers in Pharmacology, 2022
In conclusion, peripartal SSRI use and folic acid supplementation altered critical genes related to milk synthesis and mammary gland function that are important to a successful lactation. However, folic acid supplementation did not reverse changes in the mammary gland transcriptome altered by peripartal SSRI treatment. Read more
Published in BMC Genomics, 2021
Overall, our findings provide evidence that a prenatal diet rich in methyl donors can significantly alter the offspring transcriptome, including changes in isoform expression and exon usage, and some of these changes are mediated by changes in DNA methylation. Read more
Published in Biology of Reproduction, 2021
Thus, early, subluteolytic PGF pulses impact the luteal transcriptome, though not by altering steroidogenesis or causing direct inhibition of cellular function. Rather, small pulses alter pathways resulting in the removal of cellular support systems, which may sensitize the CL to later pulses of PGF. Read more
Published in Scientific Reports, 2021
Our data highlights tissue specific genes and pathways impacted by increased peripheral serotonin. In the adipose, serotonin impacted the expression of genes involved in pathways related to intracellular signal transduction mechanisms, lipid metabolism and fatty acid biosynthesis, cell proliferation and differentiation Read more
Published in BMC Genomics, 2020
Overall, our findings provide evidence that maternal nutrition can significantly alter gene coexpression patterns in the offspring, and some of these perturbations are mediated by changes in DNA methylation. Read more
Published in Animal Genetics, 2020
Overall, our findings contribute to a better understanding of the genetics underlying the reproductive performance of dairy cattle under heat stress conditions and point out novel genomic strategies for improving thermotolerance and fertility via marker-assisted breeding Read more
Published in BMC Genomics, 2020
Our findings provide evidence that maternal exposure to gossypol alters male reproductive function in the offspring, with potential lasting or lifelong negative consequences. Read more